Key result
A CRISPR-Cas9 screen identified ADAM9 as a major factor required for the early stages of encephalomyocarditis virus infection in both human and murine models.
Why the study?
Encephalomyocarditis virus (EMCV) causes viral myocarditis in rodent models, but its receptor requirements have not been fully identified.
ADAM9 is a major host dependency factor required for early stages of EMCV infection, providing a potential target for preventing viral myocarditis.
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May inform antiviral targeting of enteroviral entry; leaves open in vivo validation for myocarditis models.
Bazzone et al. (2019) studied Viral myocarditis / Encephalomyocarditis virus (EMCV) infection. CRISPR-Cas9 screen was evaluated on Host dependency factors essential for EMCV infection. A CRISPR-Cas9 screen identified ADAM9 as a major factor required for the early stages of encephalomyocarditis virus infection in both human and murine models.
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