Key result
Experimental exposure to encephalomyocarditis virus in 34 pigs resulted in 17 deaths and 7 cases of severe heart lesions, regardless of the viral dose or route of administration.
Why the study?
Does experimental encephalomyocarditis virus infection cause mortality and heart lesions in pigs?
Does experimental encephalomyocarditis virus infection cause mortality and heart lesions in pigs?
Answers are grounded in this paper and cite their sources.
Experimental infection of pigs with encephalomyocarditis virus reproduces severe heart lesions and high mortality, similar to field cases.
Encephalomycarditis virus recovered from a pig mortality in New South Wales was used to produce experimental infections. Of 34 pigs exposed, 17 died and a further 7 were found to have severe heart lesions when killed. Deaths occurred from 2 to 11 days after exposure with a mode of approximately 3 days. Ten of 11 pigs exposed by intramuscular injection died and the remaining pig was killed after 28 days and found to have severe resolving heart lesions. Of 15 pigs exposed per os to various doses of virus, 6 died, 4 were killed and found to have severe heart lesions and 5 were apparently not infected. Intranasal exposure of 8 pigs resulted in 1 death and 4 pigs with mild to severe heart lesions. Different doses of virus and routes of exposure did not substantially influence the character of the lesions. Lesions were similar to those found previously in field cases, and virus was recovered from all of 19 animals examined with severe acute lesions of 10 days standing or less.
No takes yet. Share an insight, caveat, or question.
Littlejohns et al. (1975) studied this question. Experimental exposure to encephalomyocarditis virus in 34 pigs resulted in 17 deaths and 7 cases of severe heart lesions, regardless of the viral dose or route of administration.
Synapse has enriched 10 related papers. Consider them for comparative context: