Key result
Experimental oro-nasal infection of young piglets with EMC virus B279/95 demonstrated that tonsils are the portal of entry and the heart is the target organ for progressive viral myocarditis.
Population
26 Belgian 15 kg Landrace × Pietrain piglets, sero-negative for classical swine fever virus, bovine viral…
Comparison
Oro-nasal infection with 4 mL of 10³ TCID50/mL… vs Negative controls euthanised at hour 0 (n=2)
Design
Preclinical, randomly numbered to determine their time of euthanisation
Follow-up
up to 78 hours post infection
Authors
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Offers a porcine model for viral myocarditis progression; leaves open human translation pending validation.
Experimental EMCV infection in young piglets mimics the progression and individual variability of natural viral myocarditis, providing a valuable animal model for comparative studies.
Gelmetti et al. (2005) studied Encephalomyocarditis viral infection (n=26). Oro-nasal infection with EMC virus field isolate B279/95 vs. Negative controls (uninfected) was evaluated on Pathogenesis and viral distribution (virus isolation, histological examination, immunodetection). Experimental oro-nasal infection of young piglets with EMC virus B279/95 demonstrated that tonsils are the portal of entry and the heart is the target organ for progressive viral myocarditis.
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