Key result
Intra-abdominal transplantation of myocardial or pancreatic sections from acutely EMCV-infected pigs into mice resulted in transmission of the virus and acute fatal disease in 100% of recipients.
Why the study?
Does transplantation of EMCV-infected pig tissues transmit the virus and cause fatal disease in mice?
Population
Non-mutant C57BL/6 and C57BL/6-RAG-1-/- mice (lacking B or T lymphocytes)
Comparison
Intra-abdominal transplantation of myocardial or… vs Intra-abdominal transplantation of uninfected…
Design
Preclinical
Follow-up
Up to 5 to 6 days post-transplantation for acute disease
Authors
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Warrants caution on EMCV transmission risk in porcine xenotransplantation; leaves open need for donor screening validation in future models.
Does transplantation of EMCV-infected pig tissues transmit the virus and cause fatal disease in mice?
EMCV can be efficiently transmitted from infected pig myocardial and pancreatic tissues to mice, providing a model for viral xenozoonosis in xenotransplantation.
Brewer et al. (2003) studied Porcine encephalomyocarditis virus (EMCV) infection. Transplantation of myocardial or pancreatic sections from acutely-EMCV infected pigs vs. Transplantation of tissues from chronically infected pigs or uninfected tissues was evaluated on Transmission of virus and acute fatal disease. Intra-abdominal transplantation of myocardial or pancreatic sections from acutely EMCV-infected pigs into mice resulted in transmission of the virus and acute fatal disease in 100% of recipients.
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