Key result
EMC virus D variant causes heart, brain, and pancreas damage in voles without diabetogenic effects.
Why the study?
Encephalomyocarditis virus infection in the common vole was examined for the first time to understand viral replication and tissue effects.
Answers are grounded in this paper and cite their sources.
EMC virus infection in the common vole causes viral replication and histopathological changes in the brain, heart, and pancreas, but does not exhibit a diabetogenic effect.
Encephalomyocarditis (EMC) virus infection in the common vole was examined for the first time. Sixteen 8-week-old males inoculated intraperitoneally with 10(5) plaque-forming units (pfu)/animal of the D variant of EMC virus were killed 3 and 7 days after inoculation (3 and 7 DAI). Viral replication was detected in the brain (10(5) pfu/g), heart (10(4) pfu/g) and pancreas (10(7) pfu/g) of all 8 animals at 3DAI. It was found in the pancreas (10(3) pfu/g) of all 8 animals and in the brain (10(4) pfu/g) of 2 of 8 animals at 7 DAI. Histopathological changes were observed in the brain (mild mononuclear cell infiltration around capillaries and sporadic pyknosis of neurons), heart (minimal myocardial necrosis) and pancreas (prominent acinar cell necrosis with inflammatory exudation) at 3DAI. At 7 DAI, replacement of necrotic tissues by mesenchymal cells and regeneration of acinar cells were conspicuous in the pancreas. Throughout the experimental period, no evidence for diabetogenic effect was found.
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Doi et al. (1995) studied Encephalomyocarditis (EMC) virus infection (n=16). D variant of EMC virus was evaluated on Viral replication and histopathological changes. Intraperitoneal inoculation of the D variant of EMC virus in common voles resulted in viral replication and histopathological changes in the brain, heart, and pancreas, with no diabetogenic effect.
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