January 1, 1992Journal of Veterinary Medical ScienceOpen Access

Encephalomyocarditis(EMC) Virus-Induced Myocarditis by Different Virus Variants and Mouse Strains.

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Population

Mice (diabetes-susceptible BALB/c and diabetes-resistant C57BL/6 strains)

Comparison

Inoculation with 10 PFU/head of… vs Comparison between virus variants and mouse…

Design

Preclinical

Follow-up

7 days

Authors

KHKensuke HirasawaCardiovascular Institute Hospital JHJin-Soo HanKyung Hee University MTMakio TakedaKobe University

Discussion

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Implication

Supports EMC-D BALB/c model for severe myocarditis; leaves open translation of host-virus interactions to human disease.

Structured PICO

Population

Mice (diabetes-susceptible BALB/c and diabetes-resistant C57BL/6 strains)

Intervention

Inoculation with 10(5) PFU/head of encephalomyocarditis (EMC) virus variants (highly diabetogenic EMC-D or non-diabetogenic EMC-B) intraperitoneally

Comparator

Comparison between virus variants (EMC-D vs EMC-B) and mouse strains (BALB/c vs C57BL/6)

Outcome

Development of myocarditis and heart virus titer up to 7 days post inoculationsurrogate

The severity of EMC virus-induced myocarditis is dependent on both the specific viral variant and the genetic background of the host mouse strain.

Cite This Study

Hirasawa et al. (1992) studied this question.

synapsesocial.com/papers/6a947b08beb4e1ebf564d642 https://doi.org/10.1292/jvms.54.1125

Topics

Myocarditis

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Encephalomyocarditis(EMC) Virus-Induced Myocarditis by Different Virus Variants and Mouse Strains.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Encephalomyocarditis(EMC) Virus-Induced Myocarditis by Different Virus Variants and Mouse Strains.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider