Why the study?
Does T-lymphocyte depletion alter the incidence or severity of hyperglycemia in EMC-M virus-infected DBA/2 and Balb/cBY mice?
Population
DBA/2 and Balb/cBY mice
Comparison
Infection with approximately 30 plaque-forming… vs Intact (immunocompetent) animals
Design
Preclinical
Follow-up
7 days
Authors
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Strain-specific T-cell depletion responses in mice caution against broad immune therapies; leaves open genetic stratification for future diabetes models.
Does T-lymphocyte depletion alter the incidence or severity of hyperglycemia in EMC-M virus-infected DBA/2 and Balb/cBY mice?
The study demonstrates that the pathogenesis of EMC-M virus-induced diabetes in mice is genetically influenced, with some strains experiencing direct viral beta-cell injury and others experiencing compounded immunologic damage.
Huber et al. (1985) studied this question.
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