Why the study?
Does sterile rearing compared to non-sterile rearing increase the incidence of EMC virus-induced diabetes in mice?
Population
65 male DBA/2 NCrj mice, aged 8-9 weeks at the time of inoculation.
Comparison
Sterile rearing conditions with intraperitoneal… vs Non-sterile rearing conditions with identical…
Design
Preclinical
Follow-up
4 weeks
Authors
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Sterile rearing increases EMC virus diabetes susceptibility and mortality in mice; leaves open microbiome effects on human viral diabetes risk.
Does sterile rearing compared to non-sterile rearing increase the incidence of EMC virus-induced diabetes in mice?
Mice reared under sterile conditions are significantly more susceptible to EMC virus-induced diabetes and mortality than those reared under conventional non-sterile conditions.
Shichinohe et al. (1990) studied this question.
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