Exacerbation of the Pathogenesis of the Diabetogenic Variant of Encephalomyocarditis Virus in Mice by Interferon

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Population

Adult male ICR Swiss mice and adult C57Bl/6 male mice infected with the D variant of encephalomyocarditis…

Design

Preclinical

Authors

Discussion

Warrants caution with post-infection IFN use in mice; leaves open human relevance and should not change practice.

Population

Adult male ICR Swiss mice and adult C57Bl/6 male mice infected with the D variant of encephalomyocarditis virus (EMC-D)

Intervention

Interferon (IFN beta or IFN gamma) or the IFN-inducer poly I:C administered four days after virus infection

Outcome

Frequency and severity of diabetes and symptoms of severe encephalomyocarditissurrogate

Interferon treatment exacerbates the pathogenesis of encephalomyocarditis virus in mice, worsening diabetes and inducing severe encephalomyocarditis.

Gould et al. (1985) studied this question.

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