What is the clinical evidence from this study?

Study design: Other. Population: Insulin-dependent diabetes mellitus (IDDM). Intervention: EMCV-B1 (subvariant of benign EMCV-B) vs. EMCV-D alone. Primary outcome: Production of detectable levels of IFN and interference with IDDM production by EMCV-D.

October 1, 1993Journal of Interferon Research

Interference by a Non-Interferon-Inducing Subvariant of Benign Encephalomyocarditis Virus-B with the Ability of EMCV-D to Produce Insulin-Dependent Diabetes Mellitus in ICR Swiss Male Mice

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Key result

EMCV-B1 does not induce detectable levels of interferon but retains the ability to interfere with the production of insulin-dependent diabetes mellitus by EMCV-D in ICR Swiss male mice.

Population

ICR Swiss male mice and cell culture

Comparison

Infection with EMCV-B1 vs EMCV-D alone (implied)

Design

Preclinical

Authors

DGDavid GironUniversité de Tours SYS YeiResponse Technologies (United States)

Discussion

Member takes

Implication

Non-interferon mechanisms protect beta cells from EMCV-D diabetes in mice; leaves open relevance to human type 1 diabetes.

Structured PICO

Population

ICR Swiss male mice used to study the interference of EMCV-B1 with EMCV-D-induced insulin-dependent diabetes mellitus.

Intervention

Infection with EMCV-B1 (a non-interferon-inducing subvariant of benign encephalomyocarditis virus-B)

Comparator

EMCV-D alone (implied)

Outcome

Production of interferon (IFN) and development of insulin-dependent diabetes mellitus (IDDM)surrogate

Protection of pancreatic beta cells in ICR Swiss mice by EMCV-B against EMCV-D-induced diabetes occurs by a mechanism other than interferon production.

Cite This Study

Giron et al. (1993) studied Insulin-dependent diabetes mellitus (IDDM). EMCV-B1 (subvariant of benign EMCV-B) vs. EMCV-D alone was evaluated on Production of detectable levels of IFN and interference with IDDM production by EMCV-D. EMCV-B1 does not induce detectable levels of interferon but retains the ability to interfere with the production of insulin-dependent diabetes mellitus by EMCV-D in ICR Swiss male mice.

synapsesocial.com/papers/6a947b08beb4e1ebf564d641 https://doi.org/10.1089/jir.1993.13.363

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Interference by a Non-Interferon-Inducing Subvariant of Benign Encephalomyocarditis Virus-B with the Ability of EMCV-D to Produce Insulin-Dependent Diabetes Mellitus in ICR Swiss Male Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interference by a Non-Interferon-Inducing Subvariant of Benign Encephalomyocarditis Virus-B with the Ability of EMCV-D to Produce Insulin-Dependent Diabetes Mellitus in ICR Swiss Male Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider