December 1, 1988Journal of Interferon Research

Effect of Interferons and Poly(I):Poly(C) on the Pathogenesis of the Diabetogenic Variant of Encephalomyocarditis Virus in Different Mouse Strains

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Population

Several mouse strains infected with the diabetogenic variant of encephalomyocarditis virus

Design

Preclinical

Authors

DGDavid GironUniversité de Tours HAHeidi AgostiniHuman Genome Sciences (United States)DTDonald C. ThomasAlberta Environment and Protected Areas

Discussion

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Implication

Variable IFN effects across mouse strains caution against clinical translation; leaves open optimal dosing and relevance for human studies.

Structured PICO

Population

Several mouse strains (including SWR/J, ICR Swiss, and C57BL/6 male mice) infected with the diabetogenic variant of encephalomyocarditis (EMC-D) virus

Intervention

Interferons (IFN-alpha beta) or poly(I):poly(C) administered 24 h before or 4 days after infection

Outcome

Pathogenic/diabetogenic effects of the virus and virus content in selected organssurrogate

The effect of interferons on EMC-D virus pathogenesis in mice is highly dependent on strain, interferon type, and timing of administration.

Cite This Study

Giron et al. (1988) studied this question.

synapsesocial.com/papers/6a907a2ee6af338650dd8f92 https://doi.org/10.1089/jir.1988.8.745

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Implication

Variable IFN effects across mouse strains caution against clinical translation; leaves open optimal dosing and relevance for human studies.

Effect of Interferons and Poly(I):Poly(C) on the Pathogenesis of the Diabetogenic Variant of Encephalomyocarditis Virus in Different Mouse Strains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Interferons and Poly(I):Poly(C) on the Pathogenesis of the Diabetogenic Variant of Encephalomyocarditis Virus in Different Mouse Strains

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider