Key result
Infection with the D-variant of encephalomyocarditis virus directly destroyed beta-cells to induce diabetes in mice, with no evidence of a significant immune mechanism contribution.
Why the study?
Does the immune system contribute to the pathogenesis of EMC-D virus-induced diabetes mellitus in mice?
Population
Mice
Comparison
Infection with the D-variant of… vs Heterozygous littermates and normal mice
Design
Preclinical
Authors
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Does not implicate immunity in EMC-D diabetes in mice; leaves open mechanisms of virus-induced diabetes in humans.
Does the immune system contribute to the pathogenesis of EMC-D virus-induced diabetes mellitus in mice?
This preclinical study demonstrates that EMC-D virus-induced diabetes is caused by direct viral destruction of beta-cells rather than immune-mediated mechanisms.
Yoon et al. (1985) studied Virus-induced diabetes mellitus. D-variant of encephalomyocarditis (EMC-D) virus infection vs. Heterozygous littermates, normal mice, resistant strains was evaluated on Development of diabetes / diabetogenic response. Infection with the D-variant of encephalomyocarditis virus directly destroyed beta-cells to induce diabetes in mice, with no evidence of a significant immune mechanism contribution.
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