Why the study?
Does immunization with recombinant VP1 protein prevent EMC-D virus-induced diabetes in mice?
Population
Five- to six-week-old male SJL/J mice
Comparison
Intraperitoneal immunization with purified… vs EMC-D virus-infected control mice
Design
Preclinical
Follow-up
various intervals
Authors
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Offers proof-of-concept for VP1 vaccination in this model; leaves open translation to human enteroviral diabetes prevention.
Does immunization with recombinant VP1 protein prevent EMC-D virus-induced diabetes in mice?
Immunization with recombinant VP1 protein completely prevents the development of EMC-D virus-induced diabetes in a mouse model.
Jun et al. (1995) studied this question.
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