What is the clinical evidence from this study?

Study design: Other. Population: Myocarditis. Intervention: Encephalomyocarditis (EMC) virus infection. Primary outcome: Early histopathological changes in the myocardium.

What question did this study set out to answer?

To describe and evaluate the early histopathological changes occurring in the myocardium of newborn and adult mice infected with encephalomyocarditis virus.

October 1, 1971Cardiovascular Research

Early myocardial lesions in encephalomyocarditis (EMC) virus infected mice

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Key result

Encephalomyocarditis virus infection in mice produces early histopathological changes in the myocardium consistent with direct viral invasion of the cells.

Population

Newborn and adult mice infected with encephalomyocarditis (EMC) virus

Design

Preclinical

Authors

CTC. Y. TsuiWestern University of Health Sciences GBG.E. BurchAmerican College of Cardiology HCH.L. ColcoloughTulane University

Discussion

Member takes

Implication

Offers murine model of direct viral myocardial invasion; extends experimental tools but leaves open human translation.

Key Points

To describe and evaluate the early histopathological changes occurring in the myocardium of newborn and adult mice infected with encephalomyocarditis virus.
Infected newborn and adult mice with encephalomyocarditis (EMC) virus to monitor cardiac tissue alterations.
Examined myocardial tissue and fibres using histology and electron microscopy to identify structural changes and intracellular viral particles.
Histological lesions in myocardial tissue corresponded directly with the presence of EMC virus crystals observed within myocardial fibres.
Direct intracellular invasion by the virus during infection was identified as the primary driver of early myocardial cell damage.

Structured PICO

Population

Newborn and adult mice infected with encephalomyocarditis virus to study early histopathological changes in the myocardium.

Exposure

Encephalomyocarditis (EMC) virus infection

Outcome

Early histopathological changes in the myocardiumsurrogate

EMC virus infection in mice provides a model for studying viral myocarditis, demonstrating that myocardial damage is caused by direct viral invasion.

Limitations

The relationship of EMC viral infection to cardiac disease in man is yet to be determined.

Cite This Study

Tsui et al. (1971) studied Myocarditis. Encephalomyocarditis (EMC) virus infection was evaluated on Early histopathological changes in the myocardium. Encephalomyocarditis virus infection in mice produces early histopathological changes in the myocardium consistent with direct viral invasion of the cells.

synapsesocial.com/papers/6a9ae58a1d89ef8b65608d66 https://doi.org/10.1093/cvr/5.4.550

Topics

Myocarditis

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Early myocardial lesions in encephalomyocarditis (EMC) virus infected mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Early myocardial lesions in encephalomyocarditis (EMC) virus infected mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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