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June 1, 1982Circulation

An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice.

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Population

Inbred BALB/c mice (n=125)

Comparison

Inoculation with the M variant of… vs Control mice

Design

Preclinical

Follow-up

14 days

Authors

AMAkira MatsumoriKanazawa UniversityCKC KawaiIjinkai Takeda General Hospital

Discussion

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Implication

Provides first murine model of viral myocarditis-induced HF; leaves open translation to human disease and therapies.

Structured PICO

P
Population
Inbred BALB/c mice (n=125)
I
Intervention
Inoculation with the M variant of encephalomyocarditis (EMC) virus
C
Comparator
Control mice
O
Outcome
Development of congestive heart failure, mortality, and myocardial structural changes (cavity dimensions and wall thickness)surrogate

This study establishes the first experimental animal model of congestive heart failure following viral myocarditis.

Cite This Study

Matsumori et al. (1982) studied this question.

synapsesocial.com/papers/6a86a20a5dd158e33875ec74https://doi.org/10.1161/01.cir.65.6.1230

Topics

Heart failureHFrEF treatmentMyocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early myocardial lesions in encephalomyocarditis (EMC) virus infected mice1971 · 12 citations
  2. 2Experimental Coxsackie virus B-3 and B-4 myocarditis in mice.1978 · 31 citations
  3. 3Coxsackie virus B3 perimyocarditis in BALB/c mice: Experimental model of chronic perimyocarditis in the right ventricle1980 · 76 citations
  4. 4Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis.1979 · 23 citations
  5. 5REVIEW ARTICLE1955 · 35 citations