Key result
Inoculation with the M variant of encephalomyocarditis virus caused myocardial lesions in 48.7% of BALB/c, 61.8% of C3H/He, and 66.1% of DBA/2 mice, persisting up to 8 months.
Why the study?
Does encephalomyocarditis virus inoculation induce chronic myocardial lesions resembling dilated cardiomyopathy in inbred mice?
Does encephalomyocarditis virus inoculation induce chronic myocardial lesions resembling dilated cardiomyopathy in inbred mice?
Encephalomyocarditis virus infection in susceptible mouse strains induces chronic myocardial lesions that resemble congestive (dilated) cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Validates EMCV-M model for chronic murine myocarditis; human DCM relevance remains untested.
Inbred strains of A/J, BALB/c, C3H/He, C57BL/6 and DBA/2 mice were inoculated with the M variant of encephalomyocarditis virus having a titer of 100 TCID50/0.1 ml. Myocardial lesions were seen in 73 of 150 BALB/c mice (48.7%), 160 of 259 C3H/He mice (61.8%) and 115 of 174 DBA/2 mice (66.1%). No pathologic findings were noted in A/J and C57BL/6 mice. In C3H/He and DBA/2 mice, dilatation and hypertrophy of the heart accompanying myocardial lesions persisted up to the 8th month after virus inoculation. The present study revealed that myocardial lesions similar to those in congestive (dilated) cardiomyopathy persisted for a long period after viral infection.
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Matsumori et al. (1982) studied Encephalomyocarditis virus myocarditis. M variant of encephalomyocarditis virus was evaluated on Myocardial lesions. Inoculation with the M variant of encephalomyocarditis virus caused myocardial lesions in 48.7% of BALB/c, 61.8% of C3H/He, and 66.1% of DBA/2 mice, persisting up to 8 months.
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