Key result
Inoculation with encephalomyocarditis virus caused right ventricular aneurysms in 1.1% of mice at 8 to 10 months, suggesting a pathogenetic role of viral infection in right ventricular dysplasia.
Why the study?
Does encephalomyocarditis virus infection cause right ventricular aneurysms in mice?
Population
647 inbred strains of BALB/c, C3H/He and DBA/2 mice
Design
Preclinical
Follow-up
8 to 10 months
Authors
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Hypothesis-generating for viral pathogenesis in right ventricular dysplasia; cautions against clinical extrapolation from this animal model alone.
Does encephalomyocarditis virus infection cause right ventricular aneurysms in mice?
Viral myocarditis can cause right ventricular aneurysms in a murine model, suggesting a potential viral pathogenesis for right ventricular dysplasia or Uhl's anomaly.
Matsumori et al. (1983) studied Encephalomyocarditis virus myocarditis (n=647). M variant of encephalomyocarditis virus was evaluated on Right ventricular aneurysms. Inoculation with encephalomyocarditis virus caused right ventricular aneurysms in 1.1% of mice at 8 to 10 months, suggesting a pathogenetic role of viral infection in right ventricular dysplasia.
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