Key result
Inoculation with coxsackieviruses group B types 1 or 4 resulted in left ventricular aneurysms in 14.3% of affected suckling mice, compared to 0% in matched controls.
Population
Suckling Swiss Webster mice (n=246 total; 185 infected, 61 controls)
Comparison
Inoculation with 10TCD50 of coxsackieviruses… vs Concurrently matched control mice
Design
Preclinical
Follow-up
Up to 23 days
Authors
Loading...
Establishes aneurysm as a complication of murine coxsackievirus myocarditis; leaves open relevance to human disease.
Absolute Event Rate: 14.3% vs 0%
Ventricular aneurysm is a previously undocumented complication of murine necrotizing transmural coxsackievirus myocarditis.
El-Khatib et al. (1979) studied Coxsackievirus group B, types 1 and 4 murine myocarditis (n=246). Inoculation with coxsackieviruses, group B types 1 or 4 vs. Concurrently matched control mice was evaluated on Left ventricular aneurysms postmortem. Inoculation with coxsackieviruses group B types 1 or 4 resulted in left ventricular aneurysms in 14.3% of affected suckling mice, compared to 0% in matched controls.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: