September 1, 1981The Journal of Infectious Diseases

A Mouse Model of Dilated-Type Cardiomyopathy Due to Coxsackievirus B3

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Population

Mice inoculated at 14 days of age (n=111 in the primary intervention group)

Comparison

Inoculation with coxsackievirus B3 and forced to… vs Mice infected but not forced to swim, neither…

Design

Preclinical

Follow-up

until age 15 months

Authors

MRMilagros P. ReyesUniversity of the Philippines System KDKatherine DoThe University of Texas Health Science Center at Houston FSForrest SmithOhio Department of Health

Discussion

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Implication

Hypothesis-generating mouse model of dilated cardiomyopathy; clinical translation to humans remains unproven.

Structured PICO

Population

Mice inoculated at 14 days of age (n=111 in the primary intervention group)

Intervention

Inoculation with coxsackievirus B3 and forced to swim for 30 min daily during the initial nine days of infection

Comparator

Mice infected but not forced to swim (group 2), neither infected nor forced to swim (group 1), and not infected but forced to swim (group 4)

Outcome

Cumulative mortality and pathologic changes at 15 monthshard clinical

Coxsackievirus B3 infection combined with forced swimming in young mice induces a model of dilated-type cardiomyopathy with high mortality and significant myocardial scarring.

Cite This Study

Reyes et al. (1981) studied this question.

synapsesocial.com/papers/6a70979626a7f98052dd126c https://doi.org/10.1093/infdis/144.3.232

Topics

Cardiomyopathy Cardiac amyloidosis

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A Mouse Model of Dilated-Type Cardiomyopathy Due to Coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

A Mouse Model of Dilated-Type Cardiomyopathy Due to Coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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