Why the study?
Does forced exercise augment the virulence and lethality of Coxsackievirus B-3 myocardiopathy in mice?
Population
Weanling mice with Coxsackievirus B-3 myocardiopathy induced by intraperitoneal and intracerebral…
Comparison
Forced swimming in a preheated pool during both… vs Mice with Coxsackievirus B-3 myocardiopathy not…
Design
Preclinical
Authors
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May support rest in acute viral myocarditis; leaves open translation from murine model to humans.
Does forced exercise augment the virulence and lethality of Coxsackievirus B-3 myocardiopathy in mice?
Forced exercise significantly increases mortality, myocardial necrosis, and viral replication in a murine model of Coxsackievirus B-3 myocardiopathy, supporting the clinical recommendation for rest during acute myocarditis.
Gatmaitan et al. (1970) studied this question.
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