Key result
Coxsackie B3 virus infection produced similar myofiber necrosis, mononuclear infiltration, and viral clearance times in both athymic and BALB/c mice.
Why the study?
Does Coxsackie B3 virus infection cause different myocardial pathology or viral clearance in athymic mice compared to BALB/c mice?
Population
BALB/c and athymic mice
Comparison
Coxsackie B3 virus infection vs Comparison between BALB/c and athymic mice
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
Similar pathology in athymic mice leaves open T-cell independence in Coxsackie myocarditis; requires validation in translational models.
Does Coxsackie B3 virus infection cause different myocardial pathology or viral clearance in athymic mice compared to BALB/c mice?
Athymic mice develop similar acute and chronic myocardial inflammation and viral clearance as BALB/c mice following Coxsackie B3 infection.
Robinson et al. (1981) studied Coxsackie B3 Myocarditis. Coxsackie B3 virus infection vs. BALB/c mice (compared to athymic mice) was evaluated on Myofiber necrosis, mononuclear infiltration, and viral clearance time. Coxsackie B3 virus infection produced similar myofiber necrosis, mononuclear infiltration, and viral clearance times in both athymic and BALB/c mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: