Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1978Japanese Circulation Journal-english EditionOpen Access

Experimental Coxsackie virus B-3 and B-4 myocarditis in mice.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intraperitoneal inoculation with Coxsackie virus B-3 and B-4 induce acute myocarditis and chronic myocardial fibrosis in mice?

Population

Mice (severest lesions observed between age 7 and 14 days)

Design

Preclinical

Follow-up

Up to 6 months

Authors

CKChuichi KawaiIjinkai Takeda General HospitalAMAkira MatsumoriKanazawa UniversityNKNaoie KumagaiShiga Medical Center

Discussion

Loading...

Member takes

Implication

Supports viral progression to fibrosis in mice; hypothesis-generating for human cardiomyopathy and requires clinical validation.

Structured PICO

Does intraperitoneal inoculation with Coxsackie virus B-3 and B-4 induce acute myocarditis and chronic myocardial fibrosis in mice?

P
Population
Mice (severest lesions observed between age 7 and 14 days)
I
Intervention
Intraperitoneal inoculation with recently isolated Coxsackie virus B-3 and B-4
O
Outcome
Pathological changes in the heart (myocardial necrosis, inflammation, calcification, and fibrosis)surrogate

Experimental inoculation of mice with Coxsackie virus B-3 and B-4 demonstrates that acute viral myocarditis progresses to chronic myocardial fibrosis, suggesting a role in the development of cardiomyopathy.

Cite This Study

Kawai et al. (1978) studied this question.

synapsesocial.com/papers/6a7660689d809400dabd271chttps://doi.org/10.1253/jcj.42.43

Topics

Myocarditis
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Experimental coxsackie B virus myocarditis in mice. 18 Month histopathological and virological study.1981 · 21 citations
  2. 2Postcoxsackievirus B3 Myocardiopathy in Mice1973 · 18 citations
  3. 3Ultrastructural alterations of the myocardium in Coxsackie B-3 virus myocarditis in mice. 18 Month follow-up study by transmission and analytical electron microscopy.1981 · 22 citations
  4. 4Coxsackie virus B3 perimyocarditis in BALB/c mice: Experimental model of chronic perimyocarditis in the right ventricle1980 · 76 citations
  5. 5MYOCARDITIS IN EXPERIMENTAL COXSACKIE B-3 INFECTION1959 · 53 citations