Why the study?
Does coxsackievirus B4 inoculation induce specific valvular or endocardial lesions in mice?
Population
Suckling, weanling, and adult HaM/ICR and Swiss-Webster mice
Comparison
Intraperitoneal inoculation with TC631 and… vs Vero cell-inoculated and uninoculated control mice
Design
Preclinical, studied under code
Authors
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Does not support coxsackievirus B4 causation of valvular sclerosis in mice; leaves open its role in human valvular disease.
Does coxsackievirus B4 inoculation induce specific valvular or endocardial lesions in mice?
Coxsackievirus B4 infection in mice causes age-dependent myopericarditis but does not induce specific valvular or endocardial lesions.
El-Khatib et al. (1978) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: