Key result
Coxsackievirus B4 infection in mice produced acute and chronic valvulitis, with viral antigen localizing in the stroma and endothelial cells of affected valves.
Population
Mice (experimental model of acute and chronic viral valvulitis)
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for viral valvulitis in humans, requiring prospective studies.
This preclinical study demonstrates that Coxsackievirus B4 can directly infect cardiac valves and produce valvulitis in mice, with viral antigen persisting even after tissue scarring.
Sun et al. (1967) studied Coxsackievirus B4 infection / Valvulitis. Coxsackievirus B4 infection was evaluated on Presence and localization of Coxsackie B4 virus antigen in cardiac valves and endocardium. Coxsackievirus B4 infection in mice produced acute and chronic valvulitis, with viral antigen localizing in the stroma and endothelial cells of affected valves.
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