Key result
Following acute Coxsackievirus B3 infection in young adult mice, postinfection cardiomyopathy occurred despite the clearance of virus and absence of structural viral antigen in cardiac cells.
Population
Young adult mice
Design
Preclinical
Follow-up
7 days postinfection and beyond
Authors
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Supports immune-mediated post-viral cardiomyopathy in mice; leaves open translation to human disease.
Postinfection myocarditis following Coxsackievirus B3 infection in mice occurs despite viral clearance, suggesting an immune-mediated mechanism rather than direct viral persistence.
Roesing et al. (1979) studied Coxsackievirus B3 induced heart disease. Coxsackievirus B3 infection was evaluated on Presence of structural viral antigen in cardiac cells. Following acute Coxsackievirus B3 infection in young adult mice, postinfection cardiomyopathy occurred despite the clearance of virus and absence of structural viral antigen in cardiac cells.
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