Why the study?
Does Coxsackie B4 virus inoculation produce viral nephritis and autoimmune-like reactions in mice?
Does Coxsackie B4 virus inoculation produce viral nephritis and autoimmune-like reactions in mice?
Coxsackie B4 virus can produce viral nephritis and autoimmune-like reactions in mice, suggesting a potential etiologic role in human renal disease.
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Supports viral antigen deposition in murine glomeruli; leaves open any etiologic role in human renal disease.
Coxsackie B4 virus may be highly nephrotropic. It may produce a viral nephritis and provoke an autoimmune-like reaction in the affected renal tissue of the experimentally infected mice. In this study, by means of immunonuorescent technique, both the specific viral antigen and immuno-globulin deposit were demonstrated in the glomeruli of infected mice within 5 to 8 weeks after inoculation with Coxsackie B4 virus. It is suggested that the virus may play a significant etiologic role in the pathogenesis of acute and chronic renal disease in man, of which disease the etiologic source is often unknown.
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Sun et al. (1967) studied this question.
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