January 1, 1991Autoimmunity

Coxsackievirus B4-Induced Development of Antibodies to 64,000-M r Islet Autoantigen and Hyperglycemia in Mice

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Population

Susceptible mice

Comparison

Diabetogenic Coxsackievirus B4 infection vs Noninfected control mice

Design

Preclinical

Follow-up

6 weeks

Authors

Discussion

Does not support clinical adoption; leaves open whether early intervention prevents virus-triggered autoimmunity in humans.

Population

Susceptible mice

Intervention

Diabetogenic Coxsackievirus B4 infection (with or without blood removal)

Comparator

Noninfected control mice

Outcome

64 K autoantibody development and hyperglycemiasurrogate

Coxsackievirus B4 infection in susceptible mice triggers an autoimmune response and hyperglycemia, which can be attenuated by early blood removal.

Gerling et al. (1991) studied this question.

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