September 1, 1988Journal of Medical Virology

Purification and characterization of a strain of coxsackievirus b4 of human origin that induces diabetes in mice

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Population

Mice and tissue culture cells

Comparison

Membrane-bound virions of a diabetogenic strain… vs Virions of the same strain, or a combination of…

Design

Preclinical

Authors

NCNando K. ChatterjeeWadsworth Center CNCatherine NejmanNew York State Department of Health IGIvan GerlingUniversity of Tennessee Health Science Center

Discussion

Member takes

Implication

MBVs may drive greater glucose intolerance than virions in mice; leaves open relevance to human enteroviral diabetes pathogenesis.

Structured PICO

Population

Mice and tissue culture cells

Intervention

Membrane-bound virions (MBV) of a diabetogenic strain of coxsackievirus B4 of human origin

Comparator

Virions of the same strain, or a combination of both types of particles

Outcome

Glucose intolerance (hyperglycemia) and infectivitysurrogate

Membrane-bound virions of coxsackievirus B4 are more pathogenic and induce higher glucose intolerance in mice compared to standard virions, despite being less infective.

Cite This Study

Chatterjee et al. (1988) studied this question.

synapsesocial.com/papers/6a8226d8d67698edfc463274 https://doi.org/10.1002/jmv.1890260109

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Purification and characterization of a strain of coxsackievirus b4 of human origin that induces diabetes in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Purification and characterization of a strain of coxsackievirus b4 of human origin that induces diabetes in mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider