January 1, 1983Journal of Medical Virology

Diversity within a human isolate of coxsackie B4: Relationship to viral‐induced diabetes

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Population

C57B1/6 and SWR mice

Comparison

Infection with the Edwards isolate of… vs Comparison between the different viral…

Design

Preclinical

Authors

PHPhillip C. HartigEnvironmental Protection Agency GMGordon E. MadgeVirginia Commonwealth University SWStanley R. WebbVirginia Commonwealth University

Discussion

Member takes

Implication

Strain selection modulates CB4 islet tropism in mice; leaves open human diabetogenic risk from heterogeneous isolates.

Structured PICO

Population

C57B1/6 and SWR mice

Intervention

Infection with the Edwards isolate of coxsackievirus B4 (CB4-Edw) and three of its plaque-purified virion strains (E1, E2, and E3)

Comparator

Comparison between the different viral isolates/strains

Outcome

Level of virus antigen accumulation in the islet cells as determined by immunoperoxidase localizationsurrogate

The diabetogenic potential of coxsackievirus B4 in experimental animals depends on virus strain selection due to the heterogeneous population of virion strains within human isolates.

Cite This Study

Hartig et al. (1983) studied this question.

synapsesocial.com/papers/6a8226d8d67698edfc46327a https://doi.org/10.1002/jmv.1890110104

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Diversity within a human isolate of coxsackie B4: Relationship to viral‐induced diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diversity within a human isolate of coxsackie B4: Relationship to viral‐induced diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider