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April 1, 1994Journal of Medical Virology

Complete nucleotide sequence of a beta‐cell tropic variant of coxsackievirus B4

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Population

Mouse pancreas-adapted variant of coxsackievirus B4 (P-CB4) and prototype CB4 strain (JVB Benschoten)

Comparison

Complete nucleotide sequencing vs Previously published sequence of the prototype…

Design

Preclinical

Authors

PTP. A. TitchenerUniversity of ReadingOJOwen JenkinsHealth and Safety AuthorityTST. M. SzopaRoyal London Hospital

Discussion

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Implication

Offers no immediate clinical implications; hypothesis-generating for beta-cell tropism mechanisms in coxsackievirus B4.

Structured PICO

P
Population
Mouse pancreas-adapted variant of coxsackievirus B4 (P-CB4) and prototype CB4 strain (JVB Benschoten)
I
Intervention
Complete nucleotide sequencing
C
Comparator
Previously published sequence of the prototype CB4 strain (JVB Benschoten)
O
Outcome
Nucleotide sequence differences

The identification of 25 nucleotide sequence differences between the pancreas-adapted and prototype coxsackievirus B4 strains provides a genetic basis for investigating its beta-cell tropism.

Cite This Study

Titchener et al. (1994) studied this question.

synapsesocial.com/papers/6a715b3d5d37378ac1de83bbhttps://doi.org/10.1002/jmv.1890420408
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