The P1 region of the coxsackievirus B4 genome is responsible for its virulent phenotype, including the induction of pancreatitis and hypoglycemia in mice.
Identifies P1 as CB4 virulence determinant in mice; hypothesis-generating for enteroviral therapies, pending human validation.
A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.
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Ramsingh et al. (1990) studied this question.
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