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August 1, 1993Journal of VirologyOpen Access

Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype

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Population

Mice infected with recombinant, chimeric coxsackievirus B4 constructs

Comparison

Recombinant, chimeric coxsackievirus B4 viruses… vs Virulent and nonvirulent coxsackievirus B4 strains

Design

Preclinical

Authors

MCMichele CagganaNew York State Department of HealthPCPeter ChanRoyal Victoria HospitalARArlene I. RamsinghNew York State Department of Health

Discussion

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Implication

Identifies Thr-129 VP1 as key virulence switch in murine CVB4; leaves open relevance to human enteroviral disease.

Structured PICO

P
Population
Mice infected with recombinant, chimeric coxsackievirus B4 constructs
I
Intervention
Recombinant, chimeric coxsackievirus B4 viruses and specific mutations in VP1 and VP2
C
Comparator
Virulent (CB4-V) and nonvirulent (CB4-P) coxsackievirus B4 strains
O
Outcome
Virulent phenotype in mice

A single amino acid residue (Thr-129 of VP1) determines the virulent phenotype of coxsackievirus B4 in mice.

Cite This Study

Caggana et al. (1993) studied this question.

synapsesocial.com/papers/6a85a16c02a1bc3ea31e6cb2https://doi.org/10.1128/jvi.67.8.4797-4803.1993
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