Why the study?
Do different strains of Coxsackievirus B4 cause morphological and functional damage in isolated human pancreatic islets?
Population
Isolated human pancreatic islets maintained in tissue culture
Comparison
Infection with five well-characterised strains… vs Uninfected control cells
Design
Preclinical
Follow-up
48 and 72 hours post infection
Authors
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Does not support strain-targeted interventions in clinical practice; leaves open differential roles of CBV-4 variants in beta-cell damage.
Do different strains of Coxsackievirus B4 cause morphological and functional damage in isolated human pancreatic islets?
Different strains of Coxsackievirus B4 exhibit varying abilities to replicate in and cause morphological and functional damage to human pancreatic islets in vitro.
Frisk et al. (2000) studied this question.
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