October 1, 1988Diabetes

Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-Mr Autoantigen and Glucose Sensitivity of Islets Before Development of Hyperglycemia

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Population

SJL/J and CD1 mice

Comparison

Infection with a diabetogenic strain of… vs Noninfected mice

Design

Preclinical

Follow-up

8 weeks

Authors

IGIvan GerlingUniversity of Tennessee Health Science Center CNCatherine NejmanNew York State Department of Health NCNando K. ChatterjeeWadsworth Center

Discussion

Member takes

Implication

Hypothesizes viral upregulation of islet autoantigen precedes hyperglycemia in mice; leaves open applicability to human type 1 diabetes.

Structured PICO

Population

SJL/J and CD1 mice

Intervention

Infection with a diabetogenic strain of Coxsackievirus B4 (CB4)

Comparator

Noninfected mice

Outcome

Expression of a 64,000-Mr islet antigen and glucose metabolism/beta-cell physiologysurrogate

Coxsackievirus B4 infection in susceptible mice may initiate or enhance an autoimmune reaction by increasing the expression of the 64,000-Mr autoantigen before the development of hyperglycemia.

Cite This Study

Gerling et al. (1988) studied this question.

synapsesocial.com/papers/6a8a4ed0abe412682d9321e6 https://doi.org/10.2337/diab.37.10.1419

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