January 1, 1993Autoimmunity

Lack of 64,000-M R Islet Autoantigen Overexpression and Antibody Development Following Coxsackievirus B4 Infection in Diabetes-Resistant Mice

View Full Paper

Ask AI

Bookmark

Population

Congenic B10.BR/SgSnJ H-2kTlaa mice

Comparison

Infection with a diabetogenic strain of… vs Noninfected control animals

Design

Preclinical

Follow-up

6 weeks postinfection and later

Authors

IGIvan GerlingUniversity of Tennessee Health Science Center NCNando K. ChatterjeeWadsworth Center

Discussion

Member takes

Implication

Does not support 64K autoantigen as driver of viral hyperglycemia in resistant models; leaves open its role in human disease.

Structured PICO

Population

Congenic B10.BR/SgSnJ H-2kTlaa mice

Intervention

Infection with a diabetogenic strain of coxsackievirus CB4

Comparator

Noninfected control animals

Outcome

Abnormalities of sugar metabolism, virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathologysurrogate

Diabetes-resistant mice infected with coxsackievirus B4 do not overexpress the 64K islet autoantigen or develop 64K antibodies, which may explain their resistance to virus-induced hyperglycemia.

Cite This Study

Gerling et al. (1993) studied this question.

synapsesocial.com/papers/6a8a4ecdabe412682d9321e0 https://doi.org/10.3109/08916939309077366

View Full Paper

Ask AI

Bookmark

Lack of 64,000-M R Islet Autoantigen Overexpression and Antibody Development Following Coxsackievirus B4 Infection in Diabetes-Resistant Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of 64,000-M R Islet Autoantigen Overexpression and Antibody Development Following Coxsackievirus B4 Infection in Diabetes-Resistant Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider