Why the study?
Does Coxsackievirus B4 infection alter the lymphocyte repertoire preceding the onset of hyperglycemia in diabetes-susceptible mice?
Population
Diabetes-susceptible mice
Comparison
Diabetogenic Coxsackievirus B4 infection vs Noninfected controls
Design
Preclinical
Follow-up
8 weeks postinfection
Authors
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May suggest viral effects on B-cell dynamics in diabetes models; leaves open relevance to human type 1 diabetes pathogenesis.
Does Coxsackievirus B4 infection alter the lymphocyte repertoire preceding the onset of hyperglycemia in diabetes-susceptible mice?
Coxsackievirus B4 infection induces abnormal lymphocyte maturation and alters the lymphocyte repertoire, which may contribute to the development of insulitis and hyperglycemia in susceptible mice.
Chatterjee et al. (1992) studied this question.
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