Why the study?
Does vigorous exercise increase viral replication and alter immune responses in mice with coxsackievirus B-3 myocarditis?
Population
Weanling ICR albino Swiss mice inoculated ip with 1.9 x 10(4) PFU of coxsackievirus B-3 (Nancy)
Comparison
Forced to swim vigorously daily in a preheated… vs Infected, but not exercised mice
Design
Preclinical
Follow-up
13 days
Authors
Loading...
Exercise during acute coxsackievirus infection worsens myocarditis in this model; leaves open human relevance and precludes practice change.
Does vigorous exercise increase viral replication and alter immune responses in mice with coxsackievirus B-3 myocarditis?
Vigorous exercise in a murine model of coxsackievirus B-3 myocarditis significantly increases viral replication and impairs the neutralizing antibody response.
Reyes et al. (1976) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: