Population
Inbred 3-week-old A/J mice
Comparison
Intraperitoneal inoculation with coxsackievirus… vs Mice inoculated only at 40 weeks, mice…
Design
Preclinical
Follow-up
42 weeks of age (2 weeks after second inoculation)
Authors
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Repetitive CVB3 infection induces LV dilatation in mice; hypothesis-generating for recurrent viral infection and autoimmunity in human dilated cardiomyopathy pathogenesis.
Repetitive coxsackievirus B3 infection in post-myocarditic mice induces cardiac dilatation without inflammatory cell infiltration, suggesting a role for repetitive viral infection and autoimmunity in the pathogenesis of dilated cardiomyopathy.
Nakamura et al. (1999) studied this question.
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