January 1, 2004Circulation JournalOpen Access

Identification of Autoantibodies With the Corresponding Antigen for Repetitive Coxsackievirus Infection-Induced Cardiomyopathy

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Population

Male inbred A/J mice

Comparison

Repetitive coxsackievirus B3 infection vs Control group

Design

Preclinical

Follow-up

8 weeks after the second inoculation

Authors

STSatoko TakataYamaguchi University HNHiroshi NakamuraGifu University Hospital SUSeiji UmemotoHiroshima University

Discussion

Member takes

Implication

Should not yet inform clinical myocarditis management; leaves open whether repetitive CVB3 drives autoimmune DCM in humans.

Structured PICO

Population

Male inbred A/J mice

Intervention

Repetitive coxsackievirus B3 (CVB3) infection (inoculated intraperitoneally at 3 and 40 weeks of age)

Comparator

Control group

Outcome

Mortality, fractional shortening, left ventricular dilatation, and identification of cardiac autoantigenssurrogate

Repetitive coxsackievirus B3 infection in mice induces IgM autoantibodies against alpha-cardiac actin and HSP60, which may drive subsequent dilated cardiomyopathy.

Cite This Study

Takata et al. (2004) studied this question.

synapsesocial.com/papers/6a81631d71edfdad573c7be8 https://doi.org/10.1253/circj.68.677

Topics

Cardiomyopathy Cardiac amyloidosis

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Identification of Autoantibodies With the Corresponding Antigen for Repetitive Coxsackievirus Infection-Induced Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Identification of Autoantibodies With the Corresponding Antigen for Repetitive Coxsackievirus Infection-Induced Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider