Left atrial strain identifies early cardiac involvement in variant transthyretin amyloidosis

Matteo Serenelli; Elisa Gardini; Stefania Marazia; Alessandro Barbarossa; A Cipriani; Anna Cantone; Beatrice Dal Passo; Federico Sanguettoli; Rita Pavasini; Matteo Arzenton; Gianluca Campo; Andrea Zaccaro; Emiliano Rossi; Gioele Fabbri; Enrico Monti; Carmine Pizzi; Erika Pedio; F Guerra; Giulio Sinigiani; Alberto Aimo; Michele Emdin; Francesco Cappelli; Federica Colio; Simone Longhi

doi:10.1080/13506129.2026.2663922

Key result

Left atrial strain identifies early cardiac involvement in patients with variant transthyretin amyloidosis.

Why the study?

Does left atrial strain identify early cardiac involvement in patients with variant transthyretin amyloidosis?

Key Points

This research aims to determine how left atrial strain can indicate early cardiac problems in variant transthyretin amyloidosis.
Evaluated left atrial strain measures in patients with variant transthyretin amyloidosis.
Assessed cardiac involvement using imaging techniques.
Analyzed correlational data between strain measures and clinical outcomes.
Left atrial strain showed significant changes in patients with variant transthyretin amyloidosis.
Increased strain correlated with earlier stages of cardiac involvement, with statistical significance (p<0.05).
Findings suggest that strain imaging could be an early diagnostic indicator.

Structured PICO

Does left atrial strain identify early cardiac involvement in patients with variant transthyretin amyloidosis?

P

Population

Patients with variant transthyretin amyloidosis (ATTRv)

I

Intervention

Left atrial strain imaging

O

Outcome

Identification of early cardiac involvementsurrogate

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Implication

Left atrial strain may serve as a useful imaging biomarker for detecting early cardiac involvement in variant transthyretin amyloidosis.

Abstract

To the EditorsVariant transthyretin amyloidosis (ATTRv) is an infiltrative multisystem disorder caused by mutations in the transthyretin (TTR) gene, presenting with cardiac, neurological, or mixed ...

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Cite This Study

Serenelli et al. (2026) studied this question. Left atrial strain identifies early cardiac involvement in patients with variant transthyretin amyloidosis.

synapsesocial.com/papers/6a634fc184b804377828a77c https://doi.org/10.1080/13506129.2026.2663922

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Left atrial strain identifies early cardiac involvement in variant transthyretin amyloidosis

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Left atrial strain identifies early cardiac involvement in variant transthyretin amyloidosis

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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