Key result
A metallopeptidase isolated from rat liver mitochondrial intermembrane space was identified as neurolysin, sharing biochemical properties and sequence homology with thimet oligopeptidase.
Population
Rat liver (mitochondrial intermembrane space)
Comparison
Isolation and biochemical characterization of… vs Thimet oligopeptidase (EC 3.4.24.15)
Design
Preclinical
Authors
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Mitochondrial neurolysin identification leaves human functional roles open; extends known oligopeptidase homologs beyond cytosol.
The study identifies a mitochondrial metallopeptidase from rat liver as neurolysin, revealing it as a homologue of thimet oligopeptidase.
Serizawa et al. (1995) studied this question. A metallopeptidase isolated from rat liver mitochondrial intermembrane space was identified as neurolysin, sharing biochemical properties and sequence homology with thimet oligopeptidase.
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