Key result
Radiofrequency pulmonary artery denervation linked to ~13 mm Hg reduction in residual pulmonary hypertension.
Why the study?
Does radiofrequency pulmonary artery denervation reduce pulmonary artery pressure in patients with residual pulmonary hypertension after pulmonary endarterectomy?
Observational (n=16)
Yes
Does radiofrequency pulmonary artery denervation reduce pulmonary artery pressure in patients with residual pulmonary hypertension after pulmonary endarterectomy?
Radiofrequency pulmonary artery denervation may be a safe, minimally invasive procedure to rapidly improve pulmonary hemodynamics in patients with residual pulmonary hypertension after pulmonary endarterectomy.
Answers are grounded in this paper and cite their sources.
May support PADN for residual PH post-endarterectomy; leaves open confirmation of benefit and safety in randomized trials.
OBJECTIVE: to assess the safety and efficiency of radiofrequency pulmonary artery ablation for treatment of residual pulmonary hypertension after pulmonary endarterectomy. MATERIAL AND METHODS: Radiofrequency pulmonary artery denervation (PADN) was performed in 16 patients (10 men, mean age 39 years [26; 51]). Indication for PADN was mean pulmonary artery pressure (PAP) >25 mm Hg with absence of proximal pulmonary artery lesion according to computer tomography. PADN procedure was performed with nonfluoroscopic 3D navigation system. RESULTS: After PADN mean PAP decreased from 37.3 mm Hg [29; 38] to 24.6 mm Hg [17; 30] (p=0.01); pulmonary vascular resistance decreased from 672 dyn∙s∙c-5 [387; 566] to 386 dyn∙s∙c-5 [155; 449] (р=0.02); cardiac output increased from 3.4 l/min [3.2; 3.4] to 3.5 l/ min [3.2; 4.0] (p=0.4); 6-minute walk test distance increased from 427 meters [352; 510] to 447 meters [370; 525] (p=0.16), respectively. CONCLUSION: Initial results allow to assume that radiofrequency pulmonary artery denervation combined with optimal medical therapy may take its rightful place in the treatment of this category of patients.
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Chernyavskiy et al. (2018) conducted an observational in Residual pulmonary hypertension after pulmonary endarterectomy (n=16). Radiofrequency pulmonary artery denervation (PADN) was evaluated on Mean pulmonary artery pressure (PAP) (p=0.01). Radiofrequency pulmonary artery denervation significantly reduced mean pulmonary artery pressure from 37.3 mm Hg to 24.6 mm Hg (p=0.01) in patients with residual pulmonary hypertension after endarterectomy.
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