Key result
Device-related thrombus occurs in up to 7% of patients undergoing percutaneous left atrial appendage closure and is associated with neurological ischemic events.
Why the study?
Device-related thrombus occurs in up to 7% of patients after percutaneous left atrial appendage closure and raises important concerns in a population generally ineligible for oral anticoagulation.
What are the impacts and predictors of device-related thrombus after percutaneous left atrial appendage closure?
What are the impacts and predictors of device-related thrombus after percutaneous left atrial appendage closure?
Device-related thrombus after LAAC is a significant complication associated with neurological ischemic events, highlighting the need for tailored patient selection and postprocedural antithrombotic strategies.
Device-related thrombus (DRT) is a known complication occurring in up to 7% of patients undergoing percutaneous left atrial appendage closure (LAAC). Since the target population of LAAC is generally ineligible for oral anticoagulant therapies, DRT raises important concerns. The aim of this review will be to summarize available evidence on DRT after LAAC focusing on its possible impact on outcomes. Recent findings showed a tighter association between DRT and neurological ischemic events. Antithrombotic regimen adopted after LAAC may have a protective effect against DRT. Many patient-related and procedural factors have been identified as possible predictors of DRT. A tailored approach, which takes into account DRT, is needed in the patient selection for LAAC and in the postprocedural follow-up.
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Branca et al. (2022) conducted a review in Device-related thrombus after percutaneous left atrial appendage closure. Percutaneous left atrial appendage closure (LAAC) was evaluated. Device-related thrombus occurs in up to 7% of patients undergoing percutaneous left atrial appendage closure and is associated with neurological ischemic events.
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