Key result
Elevated C-reactive protein and lung hyperinflation (IC/TLC < 36%) in stable COPD patients were associated with significantly reduced heart rate variability at rest (SDNN p=0.013 and p=0.004).
Population
30 outpatients with stable chronic obstructive pulmonary disease (COPD)
Design
Cross-sectional
Authors
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HRV assessment in stable COPD may inform autonomic risk; leaves open whether it adds prognostic value beyond lung function in larger studies.
Cross-Sectional (n=30)
p-value: p=0.013
In patients with stable COPD, moderate to severe disease is associated with abnormal cardiac autonomic modulation related to systemic inflammation and lung hyperinflation.
Corbo et al. (2012) conducted a cross-sectional in Chronic obstructive pulmonary disease (COPD) (n=30). Elevated C-reactive protein and lung hyperinflation (IC/TLC < 36%) vs. Normal CRP and IC/TLC ≥ 36% was evaluated on Heart rate variability parameters (SDNN, TFA, VLF) at rest (p=0.013). Elevated C-reactive protein and lung hyperinflation (IC/TLC < 36%) in stable COPD patients were associated with significantly reduced heart rate variability at rest (SDNN p=0.013 and p=0.004).
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