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SUMMARY: RAREMETAL is a computationally efficient tool for meta-analysis of rare variants genotyped using sequencing or arrays. RAREMETAL facilitates analyses of individual studies, accommodates a variety of input file formats, handles related and unrelated individuals, executes both single variant and burden tests and performs conditional association analyses. AVAILABILITY AND IMPLEMENTATION: http://genome.sph.umich.edu/wiki/RAREMETAL for executables, source code, documentation and tutorial.
Feng et al. (Tue,) studied this question.