Key result
High-polyphenol EVOO reduces arterial inflammation in non-calcified aortic segments over 6 months.
Why the study?
Chronic low-grade inflammation with aging contributes to cardiovascular risk, and the study aimed to evaluate arterial inflammation and microcalcification via 18F-FDG/18F-NaF-PET/CT to assess potential benefits of a tyrosol- and hydroxytyrosol-rich diet.
Does high polyphenol extra virgin olive oil reduce arterial inflammation and atherosclerotic lesion microcalcification in healthy older populations?
Does high polyphenol extra virgin olive oil reduce arterial inflammation and atherosclerotic lesion microcalcification in healthy older populations?
p-value: p=<0.004
Supplementation with high-polyphenol extra virgin olive oil, rich in tyrosol and hydroxytyrosol, significantly reduces early imaging markers of arterial inflammation and microcalcification in healthy older adults.
HP-EVOO supplementation was associated with reduced arterial inflammation in this small cohort; leaves open clinical relevance pending larger randomized trials.
Aging is an important risk factor for cardiovascular diseases and convincing data have shown that chronic low-grade inflammation, which develops with advanced age, contributes significantly to cardiovascular risk. The present study aimed to use 18F-FDG/18F-NaF-PET/CT imaging to, respectively, gauge arterial inflammation and microcalcification in a healthy elderly population and to assess the potential benefits of a tyrosol- and hydroxytyrosol-rich diet on these two markers of atherosclerotic plaque fragility. Eleven healthy participants (mean age 75 ± 5.67 years) were supplemented for 6 months with high polyphenol-rich extra virgin olive oil (HP-EVOO), extra virgin olive oil (EVOO), or refined olive oil (ROO). The participants underwent PET/CT imaging with 18F-FDG and 18F-NaF radiotracers at baseline and after 6 months. 18F-FDG and 18F-NaF uptakes were quantified using standardized uptake values (SUV) and were categorized based on artery calcification and olive oil type. A total of 324 slices of the aortas of the imaged participants were analyzed for arterial inflammation and 327 slices were analyzed for microcalcification. 18F-FDG uptake was significantly higher in the non-calcified segments than in the calcified segments (SUVmax = 2.70 ± 0.62 and SUVmax = 2.54 ± 0.44, respectively, p < 0.042). Conversely, the non-calcified segments displayed significantly lower 18F-NaF uptake than the calcified segments (SUVmax = 1.90 ± 0.37 and 2.09 ± 0.24, respectively, p < 0.0001). The 6-month supplementation with HP-EVOO induced a significant reduction in 18F-FDG uptake in both the non-calcified (2.93 ± 0.23 to 2.75 ± 0.38, p < 0.004) and calcified segments of the aortas (2.25 ± 0.29 to 2.15 ± 0.19, p < 0.02). 18F-NaF uptake was also significantly lower in patients supplemented with HP-EVOO (SUVmax = 1.98 ± 0.33 at baseline compared to 1.85 ± 0.28, after the 6-month supplementation, p < 0.004), whereas no significant effect was observed with EVOO. Conversely, participants supplemented with ROO displayed a significant increase in 18F-NaF uptake (SUVmax = 1.78 ± 0.34 to 1.95 ± 0.34, p < 0.0001). The present study confirmed that a phenolic-compound-rich diet reduces both arterial inflammation and atherosclerotic lesion microcalcification and demonstrated that 18F-FDG/18F-NaF-PET/CT imaging is a valuable approach for assessing age-related arterial damage.
No takes yet. Share an insight, caveat, or question.
Zoubdane et al. (2024) studied Healthy aging (n=11). High polyphenol-rich extra virgin olive oil (HP-EVOO) vs. Extra virgin olive oil (EVOO) or refined olive oil (ROO) was evaluated on 18F-FDG uptake (SUVmax) in non-calcified segments of the aorta at 6 months (p=<0.004). Six months of supplementation with high polyphenol-rich extra virgin olive oil significantly reduced arterial inflammation (18F-FDG SUVmax 2.93 to 2.75, p<0.004) in non-calcified aortic segments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: