What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Reduced lung function (n=9581). Intervention: Metabolic syndrome vs. Absence of metabolic syndrome. Primary outcome: Restrictive ventilatory pattern (OR 1.55, 95% CI 1.12-2.14).

January 1, 2010Journal of Korean Medical ScienceOpen Access

Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males

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Key result

Metabolic syndrome was significantly associated with an increased risk of a restrictive ventilatory pattern (OR 1.55) in apparently healthy non-smoking Korean males.

Population

9,581 apparently healthy non-smoking male adults who underwent a health examination at Kangbuk Samsung…

Design

Cross-sectional

Authors

SLSeong Yong LimKangbuk Samsung Hospital EREun‐Jung RheeKangbuk Samsung Hospital KSKi‐Chul SungPreventive Cardiology

Discussion

Member takes

Implication

Hypothesis-generating in healthy Korean males; prospective studies needed before any clinical consideration.

Study Design

Type

Cross-Sectional (n=9,581)

Multicenter

Structured PICO

Population

9,581 apparently healthy non-smoking Korean male adults were evaluated in a cross-sectional study to assess the association of lung function with insulin resistance, systemic inflammation, and metabolic syndrome.

Outcome

Association of lung function (FVC and FEV1 quartiles, and ventilatory patterns) with metabolic syndrome, insulin resistance (HOMA-IR), and systemic inflammation (hs-CRP)surrogate

Main Result

Odds Ratio: 1.55 (95% CI 1.12–2.14)

Metabolic syndrome, insulin resistance, and systemic inflammation are independently associated with reduced lung function in healthy non-smoking males, suggesting a link between metabolic health and pulmonary function.

Limitations

Cross-sectional design limits the ability to establish a cause-effect relationship
Obstructive pattern was diagnosed without post-bronchodilator assessment
Restrictive pattern was diagnosed without total lung capacity measurement
Differences between values of metabolic parameters across lung function quartiles were small, requiring further longitudinal verification
Obstructive pattern was found in only 1.4% of participants without post-bronchodilator assessment
Diagnosis of restrictive pattern was made without total lung capacity measurement
FEV1 is dependent on FVC, so quartiles of FEV1 may not exclusively reflect the degree of true airflow limitation
Cross-sectional design limits the ability to draw clear conclusions about cause-effect relationships

Cite This Study

Lim et al. (2010) conducted a cross-sectional in Reduced lung function (n=9,581). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on Restrictive ventilatory pattern (OR 1.55, 95% CI 1.12-2.14). Metabolic syndrome was significantly associated with an increased risk of a restrictive ventilatory pattern (OR 1.55) in apparently healthy non-smoking Korean males.

synapsesocial.com/papers/6a6368efa8b6909d49093c0f https://doi.org/10.3346/jkms.2010.25.10.1480

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Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider