Key result
Computer-based measurement of femoral artery lumen volume from digitized arteriograms showed coefficients of variation of 2.9% at 10 minutes and 6.1% at 11 to 13 months.
Why the study?
Does a computer-based technique for measuring lumen volume from digitized femoral arteriograms provide reproducible estimates of atheroma volume in patients with hypercholesterolemia?
Observational (n=107)
Does a computer-based technique for measuring lumen volume from digitized femoral arteriograms provide reproducible estimates of atheroma volume in patients with hypercholesterolemia?
A computer-based technique for digitizing femoral arteriograms provides highly reproducible measurements of lumen volume, offering a valid method to assess atheroma volume changes over time.
Answers are grounded in this paper and cite their sources.
Enables precise tracking of atheroma changes via femoral lumen volume in hypercholesterolemia trials; extends quantitative angiography for future RCTs.
To evaluate the effects of treatment in patients with cardiovascular risk factors, valid and reproducible methods for assessing changes in atheroma volume are required. We postulated that these changes could be accurately estimated by repeat measurement of the lumen volume of the artery to be studied. With a computer-based technique, the lumen volume of a 20 cm segment of the femoral artery was measured in arteriograms from 107 patients with hypercholesterolemia. Films were digitized with use of a high-resolution scanner, cross-sectional areas were calculated with a slice thickness of 150 microns and the lumen volume was obtained by their integration. The validity of the method was demonstrated in model experiments. An automatic algorithm to correct for changes due to patient positioning was developed and validated in a model experiment. With repeat measurement 10 min and 11 to 13 months apart the coefficients of variation were 2.9 per cent (N = 107) and 6.1 per cent (N = 29), respectively.
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Nilsson et al. (1990) conducted an observational in Hypercholesterolemia (n=107). Computer-based measurement of lumen volume from digitized arteriograms was evaluated on Coefficient of variation for repeat measurements. Computer-based measurement of femoral artery lumen volume from digitized arteriograms showed coefficients of variation of 2.9% at 10 minutes and 6.1% at 11 to 13 months.
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