Answers are grounded in this paper and cite their sources.
We report the first room-temperature direct C-2 arylation of indoles with iodoarenes by using a highly electrophilic palladium catalyst generated in situ from Pd(OAc) 2 and a silver carboxylate. These mild conditions permit a broad set of functionalities both in the indole and in the aryl iodide units such as free alcohols, phenols, aldehydes, bromides, or nitriles, thus allowing the synthesis of a variety of novel compounds in excellent yields.
No takes yet. Share an insight, caveat, or question.
Lebrasseur et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: