A method for the measurement of collagen fibre diameter in human skin is described. Photographic reduction of electron micrograph negatives onto positive transparency film allows the use of a Quantimet 720 image analysis system for relatively rapid determination of mean collagen fibre diameter based upon the mean cross-sectional area of a single electron microscope field. The mean collagen fibre diameter from papillary and reticular dermis in normal skin was 56.2 +/- 2.5 nm and 62.8 +/- 4.3 nm respectively, and exhibited slightly skewed unimodal distributions.
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Barton et al. (1984) studied this question.
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